HORDB

ID: hor002787
Uniprot ID: P58705
Protein name: Antho-KAamide
Gene name: NA
Organism: Anthopleura elegantissima (Green aggregating anemone) (Actinia elegantissima)
Family: NA
Source: animal
Expression: Neuron specific.
Disease: NA
Comments: NA
Taxonomy: Anthopleura (genus), Actiniidae (family), Actiniaria (order), Hexacorallia (subclass), Anthozoa (class), Cnidaria (phylum), Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Function: Inhibits spontaneous contractions in several muscle groups. May be involved in the expansion phase of feeding behavior in sea anemones.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002787_AF2.pdb

hor002787_ESM.pdb

Mass:	56531	Formula:	C27H37N5O5
Absent amino acids:	CDEGHILMNPQRSTVWY	Common amino acids:	F
pI:	9.7	Basic residues:	1
Polar residues:	0	Hydrophobic residues:	3
Hydrophobicity:	87.5	Boman Index:	222
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	2 min	Aliphatic Index	25
Instability Index:	-3007.5	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 1681803
Title: Isolation of L-3-phenyllactyl-Phe-Lys-Ala-NH2 (Antho-KAamide), a novel neuropeptide from sea anemones.
PubMed ID: 8397415
Title: The Expansion Behaviour of Sea Anemones May Be Coordinated by Two Inhibitory Neuropeptides, Antho-KAamide and Antho-RIamide